Chinese name: hydrocortisone
Synonyms: cortisol; cortisol; hydrocortisone; hydrocortisone; 17-hydroxy corticosterone; cortisol; hydrocortisone
English name: Hydrocortisone
11-bar, 17,21-trihydroxypregn-4-ene-3,20-dione; 11beta, 17,21-Trihydroxypregn-4 11-beta, 17-alpha, 21-trihydroxy-4-pregnene-3,20-dione; 11beta, 17alpha, 21-Trihydroxy-4-pregnene-3,20-dione; 11 -beta, 17-alpha-trihydroxypregnane-4-ene-3,20-dione; 11-beta-hydrocortisone; 11beta-Hydrocortisone
CAS: 50-23-7
Molecular formula: C21H30O5
Molecular weight: 362.46
EINECS number: 200-020-1
Steroids and hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; hormones; Insulin extract; steroid; plant extract; raw material; small molecule inhibitor; drug substance; drug substance; adrenocortical hormones' drug; Small Inhibitors, Natural Products; Pharmaceutical Ingredients
Mol file: 50-23-7.mol
Hydrocortisone
Hydrocortisone properties
Melting point 211-214 ° C (lit.)
Specific rotation of 166 º (c = 1, C2H5OH 25 ºC)
Flash point 220 ° C
Storage conditions -20 ° C
Solubility H2O: 100 mg / mL
Form powder
Decomposition 220 ºC
Merck 14,4787
BRN 1354819
Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
CAS database 50-23-7 (CAS DataBase Reference)
NIST Chemical Information Hydrocortisone (50-23-7)
EPA chemical substance information Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.) - (50-23-7)
Hydrocortisone Use and Synthesis
Chemical nature of white or almost white crystalline powder, odorless, bitter taste. Met the metamorphosis. (Ethanol), + 162 ° - + 169 ° (ethanol); ethanol solution has the largest wavelength at 242 nm (% absorb. This product is insoluble in water, insoluble in ether, slightly soluble in chloroform, soluble in acetone, ethanol. Soluble in concentrated sulfuric acid solution and green fluorescence. LD50 (rat, peritoneal) 150 mg / kg.
Use biochemical studies, adrenal cortex hormones drugs.
Use Glucocorticoids have anti-inflammatory, anti-allergy, anti-toxin, anti-shock four major effects.
Use for adrenal corticosteroids
Production method 4-pregneno-17a, 21-diol-3,20-dione-21-acetate (acetic acid compound "S") was oxidized by microorganism of Absidia Orchidis 3.65, , And purified to obtain hydrocortisone at a yield of 44%.
Production methods cortisone acetate by semicarbazide condensation, potassium borohydride reduction, sodium nitrite and hydrochloric acid treatment in the system.
Contact Person:Mr.Wu
Contact Number:027-88216882
QQ:2850515726
